Exercise Physiology
maryam Molaei Jeghanab; mandana gholami; Abdolali Banaeifar; Farshad Ghazalian
Abstract
Aim: Changes in adipokines levels play an important role in the development of different disorders including the type 2 diabetes, which among them, chemerin and omentin-1 attracted a lotof attention. In contrast, positive effect of exercise training and vitaminD consumption have been reported in combating ...
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Aim: Changes in adipokines levels play an important role in the development of different disorders including the type 2 diabetes, which among them, chemerin and omentin-1 attracted a lotof attention. In contrast, positive effect of exercise training and vitaminD consumption have been reported in combating with pathologic effects of type 2 diabetes. The aim of present study is to determine the effect of eight weeks resistance training along withvitaminD consumption on levels of chemerin and omentin-1 in type 2 diabetic patientsMethod: 40 diabetics men with average age of 47.19±3.83 years old and body fat percentage 30.96±2.49 assigned in four groups including the placebo, vitaminD, training and training+ vitaminD groups. The resistance training program conducted for eight weeks and three session per week with 60 to 70 percent of 1RM intensity. VitaminD consumption considered daily 2000 iu and placebo (oral paraffin) ingestion considered in the same amount. At the baseline and ending intervention, blood samples collected and the levels of chemerin and omentin-1 were measured and insulin resistance calculated. Data were analyzed by analysis of covariance test and Bonferroni post-hoc test.Results: The present study findings indicated that in training and training+vitaminD groups the chemerin levels significantly decreased and omentin-1 significantly increased (p<0.05). Moreover, significant decrease of insulin resistance was observed in training and training+vitaminD groups (p<0.05).Conclusion: VitaminD ingestion can increase the hypoglycemic effects of resistance training partly, which these positive effects of resistance training and vitaminD consumption exerted by increase in omentin1 levels and decrease of chemerin levels.
A Fazeli Sani; hasan Matinhomaee; A Banaeifar
Abstract
Aim: The aim of the present study was to investigate the effect of 4 weeks of aerobic exercise on cognitive function and mitochondrial dynamics in the hippocampal tissue of male Wistar rats with Alzheimer's disease.Methods: For this purpose, 21 male Wistar rats at 20 months of age were randomly divided ...
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Aim: The aim of the present study was to investigate the effect of 4 weeks of aerobic exercise on cognitive function and mitochondrial dynamics in the hippocampal tissue of male Wistar rats with Alzheimer's disease.Methods: For this purpose, 21 male Wistar rats at 20 months of age were randomly divided into 3 groups: Alzheimer's disease (n = 7), Alzheimer's disease + aerobic exercise (n = 7) and control group (n = 7). Alzheimer's disease was induced by intrahippocampal injection of Aβ42 (1 microliter per side). Seven days after surgery, the exercise group performed 4 weeks of treadmill training (5 days per week at a speed of 10 to 15 m/min). Forty-eight hours after the last training session, the animals underwent behavioral tests. Twenty-four hours after the behavioral test, all rats were killed and hippocampal tissue was extracted. The mRNA expression of OPA1, Mfn2 and Drp1 genes was assayed using Real Time-PCR. One-way analysis of variance was used for statistical analysis.Ethical Considerations: All stages of the study were conducted according to the ethical guidelines and authorization of Research Deputy of Islamic Azad University, Central Tehran Branch No. IR.IAU.TMU.REC.1399.124.Results: The results showed that spatial learning (P ≤ 0.001) and memory performance (P ≤ 0.001) as well as the gene expression of OPA1 (P ≤ 0.001) and Mfn2 (P ≤ 0.001) in animals with Alzheimer's disease decreased compared to the control group, while the gene expression of Drp1 increased (P ≤ 0.001). Aerobic exercise in patient animals improved spatial learning (P ≤ 0.001) and memory performance (P ≤ 0.001), increased hippocampal OPA1 (P ≤ 0.001) and Mfn2 (P ≤ 0.001) genes expression, and decreased Drp1 gene expression compared with Alzheimer's disease group (P ≤ 0.001).Conclusion: In general, it seems that aerobic exercise can improve spatial learning and memory performance in Alzheimer's disease by modulating abnormal mitochondrial dynamics.
